The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years.The purpose of this study is to examine the relationship between chronic insomnia and dementia biomarkers and orexin levels found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia will undergo overnight polysomnography and CSF sampling in the morning as part of protocol number 829221. These subjects will have the option to receive CBT-I and complete a second overnight PSG and and CSF sampling in the morning.

You may be eligible for this study if you meet the following criteria:

• Conditions: insomnia, dementia
• Age: 99 years or below
• Gender: All