Towards predicting the analgesic response to ibuprofen following third-molar extraction

Towards predicting the analgesic response to ibuprofen following third-molar extraction
Recruiting
18 years - 64 years
All
Phase N/A
80 participants needed
1 Location

Brief description of study

NSAIDs like ibuprofen are pain relievers that are commonly used to reduce pain after dental procedures. 
Patients who have their impacted third molar teeth taken out usually experience pain one to three hours after surgery and require pain relievers for at least 2 days. Most people (about 70-90%) experience good to excellent relief of their pain when they take ibuprofen. However, some patients experience only limited pain relief with ibuprofen, and a few experience no pain relief at all. These patients need a different type of pain reliever added to their regimen. The purpose of this study is to see if there are substances in your blood and urine which we will take both before and after your wisdom teeth surgery that can tell us how you personally will respond to ibuprofen in comparison to placebo (an inactive sugar pill). We will also study how well ibuprofen combined with acetaminophen  works for up to 7 days after surgery.

Detailed description of study

There are 4 study visits:
1) Screening - patients read and sign informed consent, urine and blood sample are taken, fill out questionnaire about mood and pain expectations.
2) Surgery - Swab of mouth to collect bacteria, urine and blood sample taken prior to surgery. Have surgery performed standard of care, receive study medication (ibuprofen 400 mg or placebo), multiple urine and blood samples (through indwelling catheter) taken, pain assessments taken, discharged with ibuprofen 400mg/acetaminophen500mg taken q4h and oxycodone 5mg if needed
3) 24 Hour Follow-up - Return visit with a single blood and urine sample
4) Day 7 Follow-up - Return visit with a single blood and urine sample

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Impacted Third Molar Tooth | Pain,Acute
  • Age: 18 years - 64 years
  • Gender: All

Study participants must be in reasonably good health and require the removal of at least one mandibular partial or full bony impacted third molar (wisdom tooth).

Updated on 19 Feb 2024. Study ID: 832417

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