Chronic insomnia and CSF markers of dementia | Clinical Research Studies Listing

Recruiting

30 years - 50 years

All

Phase N/A

30 participants needed

1 Location

Brief description of study

The purpose of this study is to identify the relationship between chronic sleep disturbance and chemicals in spinal fluid that are related to dementia and a molecule called orexin that helps regulate wakefulness and appetite in the brain. Individuals with sleep problems and good sleepers will be asked to participate.

Detailed description of study

If you agree to participate your participation will involve two visits. Both visits will take place at the Center for Human Phenomic Science (CHPS; formerly the Clinical and Translational Research Center) at the Hospital of the University of Pennsylvania. You will asked to wear an activity monitoring device called an actiwatch for one week at home. You will be asked to complete a sleep diary throughout the week. One evening, two technicians will come to your home to set you up with equipment to record your sleep overnight.

For your second visit you will come to the CHPS at 5:00 pm and be checked into the hospital. During the rest of the evening you will be free to engage in activities of your own choosing including watching TV, reading, or talking on your personal phone. During the night you are in the CHPS, your sleep will be monitored.

At 8 am, a neurologist experienced with this procedure will conduct a neurological exam prior to performing a lumbar puncture (“spinal tap”) to collect your cerebrospinal fluid (“CSF”). The exam will be used to determine if you have any medical conditions that would increase the risk of the lumbar puncture.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: dementia,insomnia
Age: 30 years - 50 years
Gender: All

Updated on 19 Feb 2024. Study ID: 829221

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