Measurement of Pulmonary Inflammation Using F-NOS Positron Emission Tomography (PET/CT) in E-cigarette Users

Recruiting
18 years - 45 years
All
Phase
N/A
60 participants needed
1 Location
Brief description of study
This is a 1 – 2 month study examining the extent of lung inflammation between e-cigarette smokers, cigarette smokers, and non-smokers using a new radio tracer, FNOS.
FNOS is an experimental radio tracer used to look for inflammation in different parts of the body. The tracer that we will be using has been shown to be safe for use on both humans and animals and allows us to examine the level of inflammation in the lungs. The level of radiation you will be exposed to is very minimal and unlikely to have any effect on you. Although some evidence suggests that e-cigarettes do not affect lung inflammation, there are very few studies that have produced data to support that. The findings of this PET scan will help scientists better understand the effects of e-cigarette smoking on the lungs.
Detailed description of study
In this study, you will participate in only 2 visits to be scheduled over the course of approximately 6 weeks:
1) a combined consent and screening visit (~3 hours)
2) one PET/CT lung scan (~3 hours)
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Nicotine Dependence,Lung Inflammation,healthy volunteer
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Age: 18 years - 45 years
-
Gender: All
To participate in this study, you must 1) be a healthy man or woman, 2) be 18-45 years old to participate, and 3) smoke cigarettes or use an electronic nicotine delivery device (e.g. e-cigarrette/vape).
**We have met our max enrollment for non-smokers and are no longer enrolling for this category, at this moment**
Updated on
19 Feb 2024.
Study ID: 831205