Pharmacokinetics of the drugs and their biological response in ECMO patients

Patients with severe pulmonary problems are occasionally placed on extracorporal membrane oxygenation ( ECMO) to provide a bridge during the time when lungs alone cannot provide necessary support. This procedure is gaining prominence but it is largely unknown how medications, especially antibiotics, given to the patient on ECMO is distributed throughout the body as compared to patients without ECMO. Since the serum level of medication determines biological activity of the drug, it is important to know if there is a difference in drug distribution between ECMO and non-ECMO patients. We already have well established data on several antibiotics on non-ECMO as a part of FDA labeling. Our study will help to determine if the concentration of currently prescribed are sufficient enough to reach their intended concentration in the study.

You may be eligible for this study if you meet the following criteria:

• Conditions: Hypoxia | Extracorporeal Membrane Oxygenation Complication
• Age: 99 years or below
• Gender: All