Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity

Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity
Recruiting
18 years - 35 years
All
Phase N/A
129 participants needed
1 Location

Brief description of study

The purpose of this study is 1) to examine the acute effects of nicotine free e-cigarette aerosol on vascular function in healthy, non-smokers and 2) to examine and compare vascular function in healthy smokers chronically exposed, at baseline and after 12 months, to nicotinized e-cigarette aerosol versus conventional cigarettes as compared to age, gender and body mass index-matched nonsmokers. Each participant, from both cohorts, will undergo 2 MRIs and 2 blood draws, per visit. All participants will be compensated for time taken to participate in the study. Key eligibility criteria include men and women, ages 18-35 with a BMI of 18.5-30. No contradictions with MRI.

Detailed description of study

Non-smokers: these participants will complete 1 study visit. The study visit will consist of 2 blood draws, 2 MRIs and 1 smoking encounter of a non-nicotine e-cigarette. These visits last around 3-3.5 hours. Smokers: these participants will complete 2 study visits. Of the smokers, there are 2 cohorts of interest: conventional and e-cigarette smokers. The baseline and 12 month visits will consist of 1 blood draw and one MRI. Each visit will last about 1.5 hours. Prior to enrollment, subjects will be asked to undergo a brief telephone screening to confirm eligibility. This will be done with either study coordinator, Alyssa Johncola or Kelly Sexton.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: healthy Volunteers, smokers, healthy subjects, Healthy, healthy controls, Smoking, Healthy volunteer, healthy, healthy volunteer, healthy volunteers, healthy subjects, healthy, healthy controls, healthy controls, smoker, e-cig, e-cigarette
  • Age: 18 years - 35 years
  • Gender: All
Updated on 19 Feb 2024. Study ID: 828195

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