While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these life-threatening conditions with any certainty. In this prospective observational study, we will investigate the many factors that contribute to the development of trauma induced coagulopathy, post injury inflammation and the development of organ dysfunction in order to develop a multi scale computational algorhythm and ex vivo models capable of clinical prediction. Using a convenience sample technique, demographic data, physiologic data, fresh and residual blood samples, urine samples, and clinical variables will be collected over 5 days following traumatic injury. In addition to a computational model, ex vivo models using microfluidic devices and high resolution cellular respirometry, and nucleic acid analysis will be used to predict the development of TIC and multi-organ failure.

You may be eligible for this study if you meet the following criteria:

• Conditions: Trauma Injury | Trauma | Coagulopathy
• Age: 99 years or below
• Gender: All