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Found 697 none trials

A listing of none medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Skeletal Muscle Perfusion and Mitochondrial Function in Heart Failure with Preserved Ejection Fraction

99 years or below
All genders
The study is being conducted to understand why the skeletal muscle of patients with Heart Failure with Preserved Ejection Fraction (HFpEF) does not work as well as the muscle of individuals without heart failure. This study seeks to understand whether the problem is with blood and oxygen delivery to the …
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Apremilast for the treatment of refractory erythema multiforme

99 years or below
All genders
Phase 2
8.0
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Effects of the Contraceptive Implant in Women with Sickle Cell Disease

99 years or below
All genders
This research is being done to see if women who have sickle cell disease (SCD) experience any difference in their pain while using a hormonal implant as compared to when not using a hormonal implant (Nexplanon). We are seeking women between the ages of 18 and 45 who have been …
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Collection of bone marrow aspirate and biopsies for research

99 years or below
All genders
We want to study the effects of immune therapy for cancer on the normal immune system. Some of the cells of the immune system reside in the bone marrow, and can only be obtained by inserting a needle into the bone marrow (typically done through the back of the hip …
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Matching Perfusion and Metabolic Activity in HFpEF

99 years or below
All genders
Phase 2
This study will test whether Potassium Nitrate (KNO3), with and without Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR), improves submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF). This study will also test whether the response to supplemental oxygen …
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CARDIOVASCULAR PULMONARY AND RENAL PHENOTYPES IN COVID-19 SURVIVORS

99 years or below
All genders
In this study, the Investigator at the University of Pennsylvania will assess organ-specific biomarker profiles (proteins and metabolites), in order to better understand biologic processes, the interplay between the heart and extracardiac organs, and their role in human disease, with an emphasis on cardiovascular disease. The study will specifically focus …
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Lymph Node Fine Needle Aspiration to Study Immune Responses to Vaccinations

99 years or below
All genders
The purpose of this study is to obtain lymph node samples to understand how the immune system makes a response to vaccinations. In particular, we will study the immune cells within lymph nodes, where we think important parts of the vaccine response occur. We believe that if we study only …
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Substudy: Understanding COVID-19 vaccine responses in the setting of immunotherapy

99 years or below
All genders
Since its emergence, SARS-Cov2 has rapidly and widely spread across the globe due to lack of prior protective immunity in the human species. With widespread mitigation measures, all efforts focused on generating effective vaccination strategies that will provide herd immunity and protect the most vulnerable populations. However, there is very …
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Spironolactone for Regulating Blood Pressure after Intracerebral Hemorrhage

99 years or below
All genders
The purpose of this research study is to determine whether blood pressure treatment regimens with spironolactone are better than blood pressure treatment regimens without spironolactone at lowering blood pressure in hemorrhagic Stroke survivors. This study will randomize a total of 200 patients, 100 of each white and nonwhite patients, between …
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Early diagnosis of transthyretin cardiac amyloidosis

99 years or below
All genders
Disease modifying therapies for ATTR transthyretin cardiac amyloidosis (ATTR-CA) promises to make a previously untreatable disease manageable. In general, cardiac amyloidosis of any type has been shown to be underdiagnosed or diagnosed late in the disease process. Our goal of the study is to identify African American (AA) patients who …
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