A Pilot Study of Network-Guided Transcranial Magnetic Stimulation for Adult ADHD

Attention Deficit Hyperactivity Disorder (ADHD) is characterized by symptoms of impulsivity, inattention, and hyperactivity that emerge in childhood and frequently persist into adulthood. These symptoms are accompanied by deficits in cognitive control and risky decision making that can lead to negative psychosocial and health-related outcomes. With advances in the neuroimaging field, we are learning where and how self-control over decisions and behaviors is executed in the brain. This work points to the central role of neural activity in the dorsolateral prefrontal cortices (DLPFC) in self-control processes that contribute to healthy choices. Further, emerging evidence shows that activity in the prefrontal cortices and cognitive control circuits can be modulated using a noninvasive and safe intervention: repetitive transcranial magnetic stimulation (TMS). Neuroimaging reveals that different subjects have distinct functional network organization even when brain anatomy looks similar between individuals. This within-subject proof of concept study will investigate whether TMS administered to two different networks thought to be involved in executive functions and attention can enhance specific functions in subjects with ADHD.

You may be eligible for this study if you meet the following criteria:

• Conditions: ADHD
• Age: 18 years - 99 years
• Gender: All